Download CURRICULUM VITAE - Instituto de Química y Bioquímica

CURRICULUM VITAE
Jaime Alberto Mella
Pharmacist, Ph. D. in Chemistry
Phone: +56-9-88088352
Office: +56-032-250 8067
e-mail: jaime.mella@uv.cl
-
Professional profile:
Ph. D in Chemistry with expertise in Organic and Medicinal Chemistry.
Research Area: Design, synthesis, biological evaluation and structure-activity
relationships of bioactive heterocycles.
Background
1. Personal History
First Name
Last name
RUT
Date of birth
City of birth
Nationality
Marital Status
Particular phone
Mobile phone
e-mail
Jaime Alberto
Mella Raipán
15.356.429-9
05-Julio-1982
Santiago
Chilean
Married
032-2508067
+56-9-8 80 88 352
jaime.mella@uv.cl
jamella@uc.cl
2. EDUCATION, QUALIFICATIONS AND DEGREES
2.1 Short review
Educational Institutions
College graduation: Instituto Nacional
Undergraduate studies: PUC, Pharmacist.
Ph. D: PUC, Chemistry
- Doctoral candidacy
- Certification exam
- Final Average
Ratings
6,4
6,4
7,0
7,0
6,9
2.2 Job title
Title name
Pharmacist
Grade Name
Graduate in Pharmacy
Ph. D in Chemistry
Institution that granted
Country
PUC
Chile
Institution that granted
Country
PUC
PUC
Chile
Chile
Obtaining
Year
2007
Obtaining
Year
2007
2012
2.2 Academic hierarchies
Hierarchy
Assistant Instructor
Assistant Professor
Institution
PUC
UV
Year
2012
2012- today
3. ACADEMIC AND WORK ACTIVITIES
3.1 Postgraduate teaching
Course
- Medicinal Chemistry (QPG3326)
- Advanced Organic Chemistry
Institution
PUC
UV
Year
2012-2014
2014
3.2 Undergraduate teaching
-
Course
Organic Chemistry I (BMR213)
Environmental Organic Chemistry (IAM212)
Organic Chemistry I, Lab. (LCBQ212)
Chemistry Lab. (QIM101A)
Organic chemistry II , Lab. (LCBQ222)
Matter structure (ICB421)
Physical Chemistry II (LCB311)
Institution
UV
UV
UV
PUC
UV
UV
UV
Year
2013-15
2013-15
2013
2012
2012
2012
2012
Institution
C. Verbo Divino
PUC
PUC
PUC
PUC
PUC.
Of. Juv. I. M. M
Year
2010
2005-10
2006-10
2005-6
2005-6
2003-4
2003-4
3.3 Teaching: assistantships and other
Course
- Chemistry (school)
- General and Organic chemistry, Tutor CARA
UC
- Chemistry, Precollege FEUC
- Organic Chemistry II
- Medicinal Chemistry II
- Medicinal Chemistry III
- Chemistry, Precollege IMM.
3.4 Thesis directed
Thesis name
Research Area
Comparative 3D-QSAR study Medicinal Chemistry and
on aminoalkylindoles as CB1 QSAR.
and CB2 agonist.
3D-
3D-QSAR design and synthesis Organic synthesis and 3D-QSAR
of new beta-3 adrenergic
ligands
Year
2013
2015-in
progress
3.5 Participation in Research projects
Project Name
―Rational design, synthesis,
biological evaluation and
quantitative structure-activity
relationships of novel ß3-AR
ligands‖
―Synthesis, binding mode
prediction, biological evaluation
and SAR analysis of
benzoimidazole-based modulators
of the endocannabinoid system‖
―Síntesis, binding, docking y 3dqsar de 2-piridil-benzimidazoles:
una nueva familia de potentes
ligandos
del receptor de cannabinoides
CB1‖
"Búsqueda de nuevos inhibidores
no nucleosídicos de la enzima
transcriptasa reversa de HIV-1:
Síntesis y evaluación biológica de
nuevos derivados
benzoimidazólicos"
Responsibility
Year
Funding
Principal
Investigator
FONDECYT
grant N°
11130701
2013-2017
Co-investigator
FONDECYT
grant N°
1150121
2015-2019
Undergraduate
student
Graduate
student
FONDECYT
grant
N°1100493
FONDECYT
grant Nº
1050950
2007-2012
2006-7
3.6 Other activities
Institution
- P. Universidad Católica
- Farmacias Cruz Verde S. A.
- Energía y Vida de Chile S.A.
- Editorial Santillana
Position
Advisory for Accreditation of PhD in
Chemistry
Supplementary Technical Director
Supplementary Technical Director
Author of Hipertext for chemistry
and mathematics to secondary school.
Year
2012
2012
2010-12
2010
4. PUBLICATIONS
4.1 Papers
Vásquez, D.; Lagos, C. F.; Mella-Raipán, J.; González, L.; Ebensperger, R.;
Álvarez-Figueroa,
M.
J.,
1-benzoyl-2-(2-nitrophenyl)-1H-benzimidazole
derivatives: A novel approach to the development of new HIV-1 reverse
transcriptase inhibitors. Journal of the Chilean Chemical Society 2007, 52 (4),
1281-1287.
Pessoa-Mahana, D.; Espinosa-Bustos, C.; Mella-Raipán, J.; Canales-Pacheco, J.;
Pessoa-Mahana, H., Microwave-assisted synthesis and regioisomeric structural
elucidation of novel benzimidazo[1,2d][1,4]benzodiazepinone derivatives. Arkivoc
2009, 131-140.
Pessoa-Mahana, D.; Nunez, A.; Espinosa, C.; Mella-Raipán, J.; Pessoa-Mahana,
H., Synthesis of a novel series of 4-arylpiperazinyl derivatives linked to a 2(pyridin-3-yl)-1H-benzimidazole as new delavirdine analogues. Journal of the
Brazilian Chemical Society 2010, 21 (1), 63-70.
Romero, M.; Rojano, B.; Mella-Raipán, J.; Pessoa-Mahana, C. D.; Lissi, E.;
Lopez-Alarcon, C., Antioxidant capacity of pure compounds and complex
mixtures evaluated by the ORAC-pyrogallol red assay in the presence of triton X100 micelles. Molecules 2010, 15 (9), 6152-6167.
Álvarez-Figueroa, M. J.; Pessoa-Mahana, C. D.; Palavecino-Gonzalez, M. E.;
Mella-Raipán, J.; Espinosa-Bustos, C.; Lagos-Munoz, M. E., Evaluation of the
membrane permeability (PAMPA and Skin) of benzimidazoles with potential
cannabinoid activity and their relation with the Biopharmaceutics Classification
System (BCS). AAPS PharmSciTech 2011, 12 (2), 573-578.
Lopez Alarcon, C.; Lissi, E.; Hoffmann, P.; Mella-Raipán, J.; Pessoa Mahana, C.
D.; Speisky, H.; al, e., Interaction of 5-aminosalicylic acid with nitrous acid:
Formation of the diazonium derivative and nitric oxide release. Canadian Journal
of Chemistry 2011, 89 (6), 628-638.
Recabarren Gajardo, G.; Gacitua, M.; Murueva, I.; Romero, J.; Espinosa Bustos,
C.; Mella Raipán, J., Synthesis, characterization, and electrochemical studies of
new 5- and 6-nitro N-acyl-1 H-indazoles. Journal of Physical Organic Chemistry
2011, 24 (12), 1179-1187.
Pessoa-Mahana, H.; Araya-Maturana, R.; Barría, C. S.; Pessoa-Mahana, D.;
Iturriaga-Vasquez, P.; Mella-Raipán, J.; Reyes-Parada, M.; Celis-Barros, C.,
Synthesis, 5-Hydroxytryptamine-1A Receptor Affinity and Docking Studies of 3[3-(4-Aryl-1-piperazinyl)-propyl]-1H-Indole
Derivatives.
Chemical
and
Pharmaceutical Bulletin 2012, 60 (5), 632-638.
Jaime A. Mella-Raipán, Carlos F. Lagos, Gonzalo Recabarren-Gajardo,
Christian Espinosa-Bustos, Javier Romero-Parra, Hernán Pessoa-Mahana, Patricio
Iturriaga-Vásquez, and C. David Pessoa-Mahana. Design, Synthesis, Binding and
Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles—A New Family of
High Affinity CB1 Cannabinoid Ligands. Molecules 2013, 18 (4), 3972-4001.
Jaime A. Mella-Raipán, Santiago Hernández-Pino, César Morales-Verdejo,
David Pessoa-Mahana. 3D-QSAR/CoMFA-Based Structure-Affinity/Selectivity
Relationships of Aminoalkylindoles in the Cannabinoid CB1 and CB2 Receptors.
Molecules 2014, 19(3), 2842-2861.
Christian Espinosa-Bustos, Javier Romero-Parra, Ana M. Zárate, Jaime MellaRaipán, Hernán Pessoa-Mahana, Patricio Iturriaga-Vásquez, Ricardo A. Tapia,
Carlos F. Lagos and C. David Pessoa-Mahana. Synthetic cannabinoid ligands: a
new series of benzimidazole-based molecules with significant binding affinity for
CB1 receptors. Arch. Pharm. Chem. Life Sci. 2015, 348, 1–8
4.2 Articles in conferences
Pessoa, D.; Mella, J.; González, L.; Sáez, E.; Espinosa, C.; Canales, J.; Pessoa, H.;
Lagos, C.; González, Á.; Pérez, T., Estudio de inhibición de la enzima transcriptasa
inversa del VIH-1 de una serie de 6-fenil benzimidazo[1,2-c][quinazolinas. XXVII
Jornadas Chilenas de Química 2007, Sociedad Chilena de Química.
Pessoa-Mahana, D.; Mella-Raipán, J.; Espinosa, C.; Sáez, E.; Canales, J.; PessoaMahana, H.; Lagos, C.; González-Wong, Á.; Pérez-Acle, T., Síntesis y modelación
molecular de benzimidazo[1,2-d][1,4]benzodiazocinonas diseñadas como
inhibidores de la enzima transcriptasa inversa del VIH-1. XXVII Jornadas Chilenas
de Química 2007, Sociedad Chilena de Química.
Mella-Raipán, J., Desarrollo racional de nuevos ligandos del receptor de
cannabinoides CB1. XXVIII Jornadas Chilenas de Química 2009, Sociedad
Chilena de Química.
Espinosa-Bustos, C.; Lagos, C. F.; Romero-Parra, J.; Mella-Raipán, J.; PessoaMahana, H.; Recabarren-Gajardo, G.; Pessoa-Mahana, C. D., Synthesis and
docking
of
new
(2-(2,5-dimethoxyphenyl)-1h-benzo[d]imidazol-1yl)(aryl)methanone derivatives designed as novel cannabinoid CB1 receptor
antagonists. . 14th Brazilian Meeting on Organic Synthesis 2011, Brazil (BMOS).
Mella-Raipán, J.; Lagos, C. F.; Romero-Parra, J.; Espinosa-Bustos, C.; PessoaMahana, H.; Recabarren-Gajardo, G.; Pessoa-Mahana, C. D., Docking and
synthesis of a
series of 1-(naphthalen-1-ylmethyl)-2-(pyridin-2-yl)-1hbenzo[d]imidazole derivatives designed as novel CB1 cannabinoid ligands. . 14th
Brazilian Meeting on Organic Synthesis 2011, Brasil (BMOS).
Romero-Parra, J.; Mella-Raipán, J.; Lagos, C. F.; Espinosa-Bustos, C.; PessoaMahana, H.; Recabarren, G.; Pessoa-Mahana, C. D., Synthesis and docking of new
benzimidazole derivates designed as novel and potent CB1cannabinoid ligands. .
14th Brazilian Meeting on Organic Synthesis 2011, Brazil (BMOS).
Mella-Raipán, J.; Pessoa-Mahana, C. D., Docking y síntesis de una serie de 1(naftalen-1-il-metil)-2-(piridin-2-il)-1H-benzo[d]imidazol diseñados como nuevos
ligandos cannabinoides CB1. . XXIX Jornadas Chilenas de Química 2011,
Sociedad Chilena de Química.
Mella-Raipán, J. Estudio 3D-QSAR comparativo de una serie de indoles con alta
afinidad por el receptor cannabinoide CB2. XXX Jornadas Chilenas de Químca,
2013, Pucón, Chile. Sociedad Chilena de Química.
Mella-Raipán, J. Pessoa, D. 2-Piridilbenzimidazoles, una nueva familia de
potentes ligandos del receptor cannabinoide CB1. XXX Jornadas Chilenas de
Químca, 2013, Pucón, Chile. Sociedad Chilena de Química.
Mella-Raipán, J.; Pessoa, D. CoMFA, una herramienta útil en el diseño de
compuestos bioactivos. XXX Jornadas Chilenas de Químca, 2013, Pucón, Chile.
Sociedad Chilena de Química.
Diana Ahumada, Javier Campanini, Juan Andrades, Jaime Mella-Raipán, David
Vásquez. Synthesis, characterization and evaluation of antibacterial activity of a
series of 8,9-bis(aryl/alkyl-thio)pyrimidoisoquinolinquinones. 31° Congreso
Latinoamericano de Química CLAQ-2014. Lima, Perú.
Pablo Parra, Javier Campanini, Juan Andrades, Nelson Pérez, Diana Ahumada,
Adriano Andricopulo, Leonardo Ferreira, Jaime Mella-Raipán, Gonzalo
Recabarren, Oney Ramirez, David Vásquez. Modeling, synthesis, characterization
and evaluation of the antibacterial activity of a series of 4R-phenylfuranbenzamides
compounds as new FtsZ inhibitors. 31° Congreso Latinoamericano de Química
CLAQ-2014. Lima, Perú.
Nelson Pérez, Juan Andrades, Javier Campanini, Pablo Parra, David Vásquez,
Jaime Mella-Raipán. 3D-QSAR/CoMFA study on acetylcholinesterase inhibitors
with potential activity in Alzheimer disease. 31° Congreso Latinoamericano de
Química CLAQ-2014. Lima, Perú.
Juan Andrades, Javier Campanini, David Vásquez, Jaime Mella-Raipán. A
Combined 3D-QSAR CoMFA and CoMSIA study on FtsZ inhibitors. 31°
Congreso Latinoamericano de Química CLAQ-2014. Lima, Perú.
D.R. Vásquez, J.A. Campanini, D.C. Ahumada, E.S. Salas, J.A. Andrades, J.A.
Mella, M.J. Kogan, C.A. Durán, R.M. Vidal and F.P. Silva. Study of antibacterial
activity and toxicity of functional analogues of ubiquinone. III International
Conference on Antimicrobial Research – ICAR-2014, Madrid, España.
5. SCHOLARSHIPS, AWARDS
Name
National score in Chemistry, PAA. 2000.
First Class Honors (2001) in Pharmacy
Institution
Year
DEMRE
2000
PUC
2001
Padre Hurtado Scholarship for Undergraduate Studies
PUC
Juan Gómez Milla Scholarship for Undergraduate
MINEDUC
Studies
Indigenous Scholarship
JUNAEB
Municipality of Santiago Scholarship by National PAA
Mun. Santiago
score, Chemistry.
USACH Scholarship per second place in Olympics
USACH
Chemistry 2000
Universidad de Chile Scholarship for Undergraduate
UCHILE
Studies.
Award for best graduate student, class of 2007
PUC
CONICYT scholarship for doctoral studies
CONICYT
Scholarship support for carrying Doctoral Thesis
CONICYT
2001
2001
2001
2001
2000
2001
2008
2007
2009
6. SHORT COURSES IN CHILE AND / OR ABROAD
Teacher, course name, location, country.
Dr. Antonio Mouriño, ―Diseño racional y síntesis
de análogos de vitamina D‖, PUC, Chile.
Lab. La Roche-Posay, Lab. Vichy, ―Especialización
en dermo-productos‖, PUC, Chile.
Funding
Year
PUC
2008
PUC, La RochePosay.
2006
7. PROFESSIONAL REFERENCES
Name
Dr. David Pessoa
Mahana
Institution
e-mail
Ex-Vicedecano Facultad de
Química P. Universidad Católica
cpessoa@uc.cl
Dr. Bruce K. Cassels
Universidad de Chile
bcassels@u.uchile.cl
Dra. María A. del
Valle de la C.
Dr. Hernán Pessoa
M.
Prof. Fernando
López S.
Dr. Mario Faúndez.
Ex-Decano Facultad de Química P.
Universidad Católica
Universidad de Chile
Cecilia Letelier
P. Universidad Católica
mdvalle@uc.cl
hpessoa@ciq.uchile.
cl
flopez@uc.cl
Sub-director Académico Facultad mfaundeza@uc.cl
de Química P. Universidad Católica
Psicóloga educacional, encargada de
CARA UC
cletelih@uc.cl