Download 1.-Graphene Microelectrodes for biomedical applications.

Portes obertes IMB-CNM 2015
Les oportunitats de les microtecnologies a l’àrea de les
aplicacions biomèdiques
GRUPO DE APLICACIONES BIOMEDICAS
Cochlear Implant
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http://www.huffingtonpost.es/2015/02/09/felicidad-escuchar-primer_n_6645614.html
https://www.youtube.com/watch?v=0B8Zj62LoUg
Mission
Take advantage of its own technological facilities and its scientific and
technical know-how, the primary mission of the Biomedical Applications
Group at CNM-IMB is to transform the innovation possibilities of microdevices and related technologies into successful commercial
biomedical products and advanced applications.
MICRO/NANOTECHNOLOGIES FOR
ADVANCED MOLECULAR TO
ORGAN BIOMONITORING
To foster and manage experimental and clinical assays that
use microsystems and transfer the microsystem technology
to the biomedical field
MiCROTRANS: Micro-probe multisensor for graft viability
monitoring during organ preservation and transplantation
CORBI: Multisensor for corneal pathologies
that can affect the corneal barrier function
Ph
Impedancia
Temperatura
Pyrex sustrate
Patent License
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A multidisciplinar group
Biomedical Application Group
TECHNOLOGIES
MEDICAL
APPLICATIONS
CHEMICAL
ENGINEERING
ELECTRONIC
ENGINEERING
Students
Grup de Recerca Consolidat 2014 SGR
6
Micro/nano technologies for advanced
molecular, celular and organ biomonitoring
BIOSENSORES
PLATAFORMAS
MULTISENSORAS
INTERFASES NEURONALES 7
Micro/nano technologies for advanced
molecular, celular and organ biomonitoring
Highligts (2010-2014)
 Development of electrochemical devices for biomedical
applications (simulation, design, fabrication and
characterization)
 Functionalization of surfaces for biosensing applications
 Standarization of technological processes using flexible
substrates (SU-8, COP, Parylene, Polyimide)
 Development of electronic instrumentation for biomedical
devices
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Micro/nano technologies for advanced
molecular, celular and organ biomonitoring
Trends for 2015…
 Graphene Microelectrodes for biomedical applications
 Biomimetic microfluidics microchambers : Organ on a chip
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1.-Graphene Microelectrodes for biomedical applications.
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1.-Graphene Microelectrodes for biomedical applications.
Graphene -Transistor / flexible-sustrates.
Graphene
Au
Local Field Potencial Neural Recording
JAE INTRO 2015 (25 MAYO)
JAEINT_EX15_0076: Desarrollo de un sistema de instrumentación para caracterizar electroquímicamente SGFETs basados en grafeno
JAEINT_EX15_0481: Diseño y simulación de biosensores impedimétricos basados en variaciones de la conductividad superficial
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Fabrication steps: Challenges
1cm
Neurological Recording with
Graphene
The objectives of this project are to
validate graphene as a brain interface
material, to develop devices for
recording neural activity.
2012-2022
BIOMEDICAL TECHNOLOGIES
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2.
ORGAN ON A CHIP.
+
 The convergence of Lab-on-Chips (LOCs) and cell biology has permitted the study of
human physiology in an organ-specific context, introducing a novel model of in vitro
multicellular human organisms.
 An Organ-on-a-Chip (OC) is a multi-channel 3-D microfluidic cell culture chip that
simulates the activities, mechanics and physiological response of entire organs and
organ systems.
 One day, they will perhaps abolish the need for animals in drug development and toxin
testing.
Air flow
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Science. 2012 Jun 25
Reconstituting organ-level lung functions on a chip.
European Commission. Full EU Ban on Animal Testing for
Cosmetics Enters into Force (2013)
GLIOBLASTOMA
• El glioblastoma es la forma más agresiva de cáncer cerebral
• En los lactantes y niños pequeños los tumores cerebrales son la
segunda forma más común de cáncer, después de la leucemia.
• En los adultos la incidencia anual de estas neoplasias oscila
según edad entre 5 y 11 por 100 mil habitantes
• En los últimos años apenas se han incorporado novedades a su
tratamiento.
BARRERA HEMATO ENCEFALICA
BLOOD – BRAIN BARRIER
(BBB)
blood
blood
BLOOD-BRAIN BARRIER
Permeability Measurement: TRANSWELL
ORGAN ON A CHIP: BLOOD-BRAIN BARRIER
ORGAN ON A CHIP
THANKS!!!
ANIMO!!
rosa.villa@csic.es
http://gab.imb-cnm.csic.es/