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Parity History Determines a Systemic Inflammatory Response to Spread
of Ovarian Cancer in Naturally Aged Mice
Urzua Ulises 1, 4, 5 ;Chacon Carlos 1 ;Lizama Luis 2 ;Sarmiento Sebasti#cod#x000E1;n 1 ;Villalobos P#cod#x000ED;a 1 ;Kroxato
Bel#cod#x000E9;n 1 ;Marcelain Katherine 3, 5 ;Gonzalez Mar#cod#x000ED;a-Julieta 4 ;
1 Laboratorio de Gen#cod#x000F3;mica Aplicada, Facultad de Medicina, Universidad de Chile ; 2 Programa de Virolog#cod#x000ED;a,
ICBM ; 3 Programa de Gen#cod#x000E9;tica Humana, ICBM ; 4 Programa de Biolog#cod#x000ED;a Celular y Molecular, ICBM ; 5
Departamento de Oncolog#cod#x000ED;a B#cod#x000E1;sica y Cl#cod#x000ED;nica, Facultad de Medicina, Universidad de Chile,
Santiago, Chile. ;
Figure 4. Tumor spread and survival of host aged mice. A Demonstrative image of intraperitoneal tumor implants formed in a 19 months-old virgin C57BL6 female mouse
injected with MOSE cells. Tumor implants in the omental fat band are shown pulled-out with clamps. B Survival plots of virgin and multiparous aged mice injected with IG-10
MOSE cells; day 0 corresponds to 16.1 #cod#x000B1; 0.3 months of age for the two groups. Median survivals were 98 and 87 days for the multiparous and virgin groups,
respectively. The p value of log-rank Mantel-Cox is shown. Both the log-rank and the Gehan-Breslow-Wilcoxon p =0.038 tests were performed in GraphPad Prism 5 with
95#cod#x00025; CI of 0.7638-1.489 for ratios of survival.
null,null,0(0),null-null. Doi:10.14336/AD.2017.0110